Microsatellite-instability-high (MSI-H) cancers form a spectrum of solid organ tumors collectively known Targets as Lynch Syndrome cancers, occurring not only in a subset of colorectal, endometrial, small bowel, gastric, pancreatic, and biliary tract cancers but also in prostate, breast, bladder, and thyroid cancers.Patients with Lynch Syndrome har
FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1
Summary DNA damage response (DDR) and the centrosome cycle are two of Baby Toiletries the most critical processes for maintaining a stable genome in animals.Sporadic evidence suggests a connection between these two processes.Here, we report our findings that six Fanconi Anemia (FA) proteins, including FancI and FancJ, localize to the centrosome.Int
The evolutionary history of mariner elements in stalk-eyed flies reveals the horizontal transfer of transposons from insects into the genome of the cnidarian Hydra vulgaris.
The stalk-eyed flies (Diopsidae, Diptera) are a family of approximately 100 species of calypterate dipterans, characterised by extended head capsules.Species within the family have previously been shown to possess six subfamilies of mariner transposons, with nucleotide substitution patterns suggesting that at least two subfamilies are currently act
Sting, Carry and Stock: How Corpse Availability Can Regulate De-Centralized Task Allocation in a Ponerine Ant Colony.
We develop a model to produce plausible patterns of task partitioning in the ponerine ant Ectatomma ruidum based on the availability of living prey and prey corpses.The model is based on the organizational capabilities of a "common stomach" Reclining Wheelchairs through which the colony utilizes the availability of a natural (food) substance as a m